Development of efficient bone marrow transplantation and its application for treatment of malignant tumor or regeneration therapy

骨髓内骨髓移植（IBM-BMT）是一种比传统静脉内骨髓移植（BMT）更有效的骨髓移植方法。在本研究中，我们对IBM-BMT使用了磁珠和磁铁。首先，我们用磁珠包裹供体骨髓细胞（BMCs）。接下来，我们将供体骨髓干细胞移植到胫骨的受体骨髓中。当供体骨髓干细胞被注射到骨头中时，在骨头周围设置了一个强大的磁铁。使用磁珠和磁铁的IBM-BMT显示供体骨髓干细胞造血迅速。

Intra-bone marrow-bone-marrow transplantation(IBM-BMT) is more efficientmethod for bone marrow transplantation than conventionalintra-venous bone marrow transplantation(BMT). In this study, we used magnet-beads and a magnet for IBM-BMT. First, we coated donor bone marrow cells(BMCs) with magnet-beads. Next, we transplantedthe donor BMCs into the recipient bone marrow of the tibia. A powerful magnet wascircumferentiallyset around the bone when the donor BMCs were injected into the bone. IBM-BMT with magnet-beads and a magnet showed rapid hematopoiesis of donor BMCs.