Strategy used to infect macrophages by the zoonotic bacteria Leptospira

我们在这项研究中研究了致病性钩端螺旋体感染巨噬细胞的机制。在吞噬体中发现致病性钩端螺旋体。然而，收购溶酶体标志物落后于非致病性钩端螺旋体的吞噬体。在感染致病性钩端螺旋体的巨噬细胞中，在感染后24小时在空泡内发现完整的钩端螺旋体，而非致病性钩端螺旋体被降解。此外，致病性钩端螺旋体的人口被释放到细胞外环境。

We examined in this study the mechanism of macrophage infection by pathogenic Leptospira. Pathogenic leptospires were found within phagosomes. However, acquisition of lysosomal markers lagged behind that of non-pathogenic leptospires-containing phagosomes. In macrophages infected with pathogenic leptospires, intact leptospires were found within vacuoles at 24 hours post infection, while non-pathogenic leptospires were degraded. Furthermore, a population of pathogenic leptospires was released to the extracellular milieu.