Targeting anticancer drug delivery to colon cancer cells using a fucose-bound nanoparticle approach

岩藻糖基转移酶(FUTS)的高表达在结肠腺癌细胞中很常见。FUTS是通过不同唾液酸前体岩藻糖基化加速恶性转化的关键酶，提示结肠腺癌细胞对L岩藻糖的关键需求。我们开发了L-岩藻糖结合的脂质体，作为向这些细胞特异性输送抗癌药物的载体。我们报道了静脉注射含有顺铂的L岩藻糖结合脂质体成功地传递到结肠癌细胞，在荷瘤小鼠中介导了有效的肿瘤生长抑制。

Increased expression of fucosyltransferases(FUTs) is common in colic adenocarcinoma cells5. FUTs are key enzymes accelerating malignant transformation through the fucosylation of different sialylated precursors, suggesting a crucial requirement for L-fucose by colic adenocarcinoma cells. We developed L-fucose-bound liposomes as vehicles for delivery of anticancer drugs specifically to these cells. We report that intravenously injected L-fucose-bound liposomes containing Cisplatin were successfully delivered to colic cancer cells, mediating efficient tumour growth inhibition in tumour-bearing mice.