Investigation of the mechanism by which FSP27 can efficiently store triglyceride as intracellular lipid droplets.

我们进行了FSP 27的结构-功能分析，以阐明FSP 27增加脂肪细胞中脂滴大小的机制。我们发现小鼠FSP 27的羧基端结构域（氨基酸：130-239）是必需的，足以增加脂滴的大小。此外，我们发现FSP 27的这个结构域与全长FSP 27一样相互作用。我们推测脂滴上的FSP 27可以通过COOH末端结构域相互作用来驱动脂滴的融合。

We performed the structure-function analysis of FSP27 to clarify the mechanism by which FSP27 increases the size of lipid droplet in adipocytes. We found that the COOH-terminal domain(amino acid : 130-239) of mouse FSP27 was necessary and enough to increase the size of lipid droplet. In addition, we showed that this domain of FSP27 interacted with each other as the full length of FSP27 did. We suppose that FSP27 on lipid droplets can drive the fusion of lipid droplets by interacting with each other through the COOH-terminal domain.