Mechanism of severity of emerging rickettsial infection, Japanese spotted fever.

最近，新出现的立克次体感染，日本斑点热（JSF：日本立克次体感染）正在成为日本的主要立克次体病。许多严重的患者被报道，但是我们没有适当的化疗来从这种传染病的严重状态中恢复。在这项研究中，我们提出了一个有效的联合化疗，使用四环素类和氟喹诺酮类药物同时治疗JSF。许多重症患者血清中TNF-α浓度升高。在体外实验中，四环素类药物抑制TNF-α的产生，而氟喹诺酮类药物则促进TNF-α的产生。这种联合化疗是JSF的合适治疗的候选者。

Recently, emerging rickettsial infection, Japanese spotted fever(JSF : Rickettsia japonica infection) is becoming a major rickettsioses in Japan. Many severe patients are reported, however we don' t have an appropriate chemotherapy to recover from the severe state of this infectious disease. In this research we present an effective combined chemotherapy for JSF using tetracyclines and fluoroquinolons simultaneously. Many severe cases showed high concentration of TNF-αin the serum. In vitro assay, the TNF-αproduction was suppressed by tetracyclines, and this phenomenon was accelerated by a part of fluoroquinolons. This combined chemotherapy is a candidate for suitable treatment of JSF.