Pathological study of higher brain dysfunction as a neurological outcome in extremely preterm infants

最近，包括多动和学习障碍在内的更高的大脑功能障碍被强调为极早产儿的神经后果。我们推测，极早产儿的脑缺血可能会导致神经元迁移到皮质，从而损害发育中的大脑皮层，导致更高的大脑功能障碍。在这项研究中，我们试图建立一种产前缺血性脑损伤的小鼠模型，并描述极早产儿较高脑功能障碍的细胞病理学基础。

Recently, higher brain dysfunction including hyperactivity and learning disability have been highlighted as neurological outcome of the extremely preterm infants. We hypothesized that the brain ischemia in the extremely preterm infants may result in injuries to the neurons migrating to cortex, subsequently damaging the developing cerebral cortex and causing higher brain dysfunction. In this study, we sought to establish a mouse model for prenatal ischemic brain injuries and delineated the cellular pathological basis for the higher brain dysfunction in extremely preterm infants.