Effective systems delivering drugs to the skin using nanoneedle

将治疗分子引入靶向器官的给药系统的发展必将推动临床治疗的进步。我们非常关注一种纳米针方法。含有药物的针头进入皮肤，被折断，留在那里，将药物释放到皮肤上。在这项研究中，我们首先检查了针的合适长度，然后检查了针的材料特性。接下来，我们试图使用纳米针将一些染料引入皮肤，我们在皮肤中发现了染料。然而，在临床应用方面，蛋白质和基因的转化率还不够高，需要进一步提高转化率。综上所述，这种方法被认为是潜在的将分子输送到皮肤中。

Development of the delivery systems which can introduce therapeutic molecules into targeting organs surely make a progress of treatments in clinical practice. We pay strong attention to a nanoneedle method. The needles containing drugs go into the skin, are broken, are remained and release the drugs to the skin. In this study, we first examined the appropriate length of the needle and then checked material properties of the needle. Next, we tried to introduce some dye into skin using the nanoneedles and we found the dye in the skin. However, introducing rate was not enough for protein and genes in the aspect of clinical use and we need to improve the introducing rate. In conclusion, this method is suggested to be potential for delivering the molecules into the skin.