Kicking and biting behavioral responses toward mechanical touch stimuli in stress-disorder model mouse

易怒是精神障碍和/或发育障碍患者中广泛出现的DSM-IV症状。易怒的行为症状也出现在实验室精神病学模型动物中，如应激和/或抑郁障碍。然而，在使用实验动物的研究中尚未报道易怒的行为范式。精神病动物模型易怒性评估方案的建立是研究精神药物评价的必要条件。在本研究中，我们开发了一种新的研究仪器，可以检测和记录触摸逃避行为和对无生命机械刺激的攻击行为的强度和发生率。本研究评估了慢性应激小鼠的易怒性，并以触觉逃避行为和攻击行为为范式评估了精神药物对易怒性的影响。本研究表明，这两种反应都可以作为烦躁性定量分析的行为范式。这两种范式似乎都对反复使用同一个体的精神药物药物评价有用。

Irritability is a widely occurring DSM-IV symptom in patients with psychiatric disorders and/or developmental disorders. Behavioral symptoms of irritability also occur in laboratory psychiatric model animals such as stress and/or depression disorders. However, behavioral paradigms for estimation of irritability have not been reported in studies using laboratory animals. Establishment of protocols for estimation of irritability in psychiatric animal models is needed to study psychotropic drug evaluations. In the present study, we developed a new research apparatus that can detect and record intensities and incidence rates of touch escape behavior and aggressive behavior toward inanimate mechanical stimuli. We estimated irritability in chronically stressed mice and evaluated the effects of psychotropic drugs on irritability using the touch escape behavior and aggressive behaviors as paradigms. The present study suggests that both responses can be used as behavioral paradigms in quantitative analyses of irritability. Both paradigms appear to be useful for drug evaluation of psychotropic agents using the same individuals repeatedly.