Inhibition of cell proliferation of human endometriotic cells by parthenolide

本研究的目的是调查芹菜素（类黄酮）和小白菊（植物小白菊）作为子宫内膜异位症的可能治疗剂的有用性。(1)芹菜素抑制有丝分裂活性和前列腺素E2的合成在增生性基质细胞（ESCs）。(2)在孤雌激素预处理的情况下，诱导的IL-8表达在ESC中被抑制。肿瘤坏死因子诱导的考克斯-2表达和PGE 2合成也受到抑制。孤雌菊通过抑制NF抑制ESCs增殖。B途径，使用小鼠子宫内膜异位症模型，施用孤雌激素显著减少子宫内膜异位症病变。

The aim of this study was to investigate the usefulness of apigenin(flavonoid) and parthenolide(plant feverfew) as a possible therapeutic agent for endometriosis.(1) Apigenin suppressed mitogenic activity and PGE2 synthesis in endometriotic stromal cells(ESCs).(2) With parthenolide pretreatment, TNF.-induced IL-8 expression were repressed in ESCs. TNF.-induced COX-2 expression and PGE2 synthesis were also inhibited. Parthenolide suppressed ESCs proliferation by inhibition of NF. B pathway, Using the murine endometriosis model, administrating parthenolide significantly reduced the endometriotic lesions.