Pathophysiology of pregnancy related cerebrovascular disease.

为了阐明妊娠相关脑血管疾病的病理生理学，我们进行了这项初步的体内研究。急性高血压时血脑屏障通透性与晚孕大鼠和非孕大鼠无明显差异。脑自动调节机制可能发生突破所需的升压剂剂量明显大于未孕大鼠。两组大鼠脑水肿形成的区域均以枕叶为主，但非孕大鼠脑水肿的分布范围更广。这些差异可能与妊娠相关的自主神经功能和血管内皮功能有关。

To clarify the pathophysiology of pregnancy related cerebrovascular disease, we conducted this preliminary in vivo study. There was no difference BBB permeability during acute hypertension compared with late pregnant rats and non-pregnant rats. The required dose of presser agents to elevate blood pressure that the brain autoregulation mechanism breakthrough probably occurred was significantly great late pregnant rats than non pregnant rats. The areas of brain edema formation in both groups were mainly occipital lobes, but more widely spread in non-pregnant rats. Those differences might be affected by pregnancy related automatic nerve function and vascular endothelial functions.