The identification and prevention of the mechanism of photoreceptor cell death

我们发现斑马鱼光感受器细胞死亡模型ovl显示光感受器细胞死亡与光传导级联有关。细胞死亡机制通过腺苷酸环化酶在转导和光转导上联系在一起。然后，我们建立了含有人类Q344X突变视紫红蛋白的RP斑马鱼模型。在该模型和其他哺乳动物RP模型中观察到光感受器细胞死亡的机制，将成为RP治疗的新靶点。

We revealed that zebrafish photoreceptor cell death model ovl shows photoreceptor cell death which relates phototransduction cascade. The cell death mechanism connects at transducine with phototransduction via adenylyl cyclase. Then we established RP zebrafish model which possesses human Q344X mutated rhodoposin. The mechanism of photoreceptor cell death was observed in this model and other mammalian RP model and will be a novel target of RP theraphy.