Development of Inhibitors for Serine-Threonine Protein Phosphatase

我们对PP1和PP2A特异性抑制剂的开发很感兴趣，这将有助于细胞信号转导的机制阐明，并将其作为最终目标。为此，作为第一步，我们尝试寻找PP1和PP2A酶的特定底物。我们期望特定的底物可以通过部分结构转化转化为特定的抑制剂。结果，我们成功地找到了PP1的特异性底物。

We were interested in development of specific inhibitors for PP1 and PP2A, which would be expected to contribute to mechanistic elucidation of a cellular signal transduction as a final goal. For the purpose, we tried to search for specific substrates for the enzymes, PP1 and PP2A, as a first step. We expected that the specific substrate could be transformed into a specific inhibitor by a partial structural transformation. As a result, we succeeded to find the specific substrate for PP1.