Development of a sensing system for thrombus formation factors produced by periodontopathic bacterium.

为了探讨牙周炎与心肌梗死的关系，我们研制了一种牙周病原菌产生血栓形成因子的传感系统。结果，我们观察到巨噬细胞在内毒素存在时增加了斑块的形成。此外，感染伴生放线杆菌后，斑块的形成减少。我们发现巨噬细胞中泡沫细胞的形成在低密度脂蛋白的刺激下显著增强。

To investigate the relation between periodontitis and myocardial infarction, we have developed a sensing system for thrombus formation factors produced by periodontopathic bacterium. As a result, we observed increased plaque formation by macrophages in the presence of LPS. In addition, the plaque formation was decreased after infection with Aggregatibacter actinomycetemcomitans. We showed that foam cell formation in macrophages was significantly enhanced by stimulation of LDL.