The responsiveness of dendritic cells against periodontitis-associated bacterial components at high glucose condition.

高糖培养的小鼠脾树突状细胞CD80、CD86高表达，IL-12p35、IL-12/IL-23p40、干扰素-γ基因表达及IL-12/IL-23p40产生明显增加。一方面，在高糖和低糖条件下，IL-4和IL-10基因的表达没有差异。这些结果表明，高糖条件刺激树突状细胞，导致对牙周炎相关细菌的反应性增加。

High levels of CD80 and CD86 expressions, IL-12p35, IL-12/IL-23p40,IFN-gamma gene expressions and IL-12/IL-23p40 production were confirmed in dendritic cells isolated from mouse spleen cultured with high glucose. On one hand, there were no differences of IL-4 and IL-10 gene expressions between high glucose and low glucose condition. These results showed that high glucose condition stimulates dendritic cells and leads to increase the responsiveness against periodontits-associated bacteria.