Stress assessment in patients with lung cancer undergoing chemotherapy

本研究采用主观和客观评估工具，对肺癌患者的应激状态及应激相关因素进行了调查。研究对象包括28名住院接受化疗的肺癌患者。参与者的唾液样本收集约2周。他们还在化疗前和化疗后7天完成了POMS和QOL问卷。结果表明，化疗后第7天唾液分泌型IgA水平明显高于化疗前。化疗第7天紧张焦虑评分较化疗前降低。此外，唾液皮质醇水平与生活质量总分呈负相关。提示化疗前患者存在以紧张、焦虑为主的应激反应，且应激水平越高，生活质量越低。

This study investigated the stress state and the factor related stress in patients with lung cancer using subjective and objective assessment tools. The subjects included 28 peoples who received chemotherapy for lung cancer in hospital. Salivary samples of the participants were collected about 2 weeks. They also completed the POMS and QOL questionnaires before and the 7 day after chemotherapy. As a result, the salivary secretory IgA level was significantly higher at the 7th day after chemotherapy than before chemotherapy. The tension-anxiety score were lower at day 7 of chemotherapy than before chemotherapy. In addition, a negative correlation was observed between the salivary cortisol level and the QOL full score. It was suggested the patients have stress mainly tension and anxiety before chemotherapy, and the higher the level of stress, the lower the level of QOL.