A neuropsychological study for resolution of pathology in the prefrontal dysfunction

旨在阐明以精神分裂症为中心的前额叶功能障碍的病理学基础和前额叶功能的作用。这项研究表明，精神分裂症患者未能使用语义组织策略进行记忆可能与额下回体积减少有关。从记忆功能和控制功能两个方面，功能影像学研究显示前额叶背外侧区和内侧区在功能上的差异更加明显。虽然额叶损伤的患者在神经心理测试中表现较差，但这表明受损区域的功能不同。

It aimed at clarifying the neural base of pathology of prefrontal dysfunction centering on schizophrenia and the role of prefrontal function. This study suggests failure to use a semanticorganization strategy for memory in schizophrenia might be related to reduced volume in the inferior frontal gyrus. The difference of function between dorso-lateral and medial prefrontal area became more clear from memory function or control function using functional neuroimaging. Although patients with frontal lobe damage showed worse performance in neuropsychological tests, it was suggested that the functions to fall by damaged area differ.