Mechanism of DNA methylation inheritance by Dnmt1

DNA甲基转移酶1（Dnmt 1）在哺乳动物基因组DNA甲基化遗传中起重要作用。Dnmt 1以细胞周期依赖性方式定位于DNA复制灶。然而，它仍然是难以捉摸的Dnmt 1的结构域需要这个过程以及如何调节这个过程。通过扫描诱变，我们确定了Dnmt 1定位的调节所需的几个域。我们的研究结果表明，分子内的相互作用是重要的Dnmt 1定位。

DNA methyltransferase 1(Dnmt1) plays an important role in the inheritance of genomic DNA methylation in mammals. Dnmt1 localizes to DNA replication foci in a cell-cycle-dependent manner. However, it remains elusive which domains of Dnmt1 are required for this process and how this process is regulated. By scanning mutagenesis, we identified several domains required for the regulation of Dnmt1 localization. Our results suggest that the intra-molecular interaction is important for Dnmt1 localization.