Crosstalk between nuclear receptor and transcription cofactor on brain development and its modulation by environmental chemicals.

使用甲状腺激素(TH)对上述主题进行分析。TH受体系统作为模型系统。先天性甲状腺功能低下大鼠在新环境下表现为多动。我们发现，这种作用是由于TH调节的微管蛋白表达减少而导致多巴胺运输中断所致。在原代小脑培养中，TH诱导树突和轴突延长，这一作用可被多溴二苯醚(PBDE)等环境化学物质抑制。PBDE不改变tr辅因子结合。相反，它将tr与DNA分离。

Above-referenced theme was analyzed using thyroid hormone (TH) . TH receptor (TR) system as a model system. Congenital hypothyroid rat showedhyperactivity under novel environment. We found that the effect is induced by disruption of dopamine transport due to a decreased tubulin expression, which is regulated by TH.In primary cerebellar culture, TH induced an increase in dendrite and neurite elongation,which was inhibited by environmental chemicals such as polybrominated diphenylether(PBDE). PBDE did not alter TR-cofactor binding. Instead, it dissociated TR from DNA.