Study of pathogenic mechanism of autoimmune diseases using the evidence from anti-IL-6 therapy

本研究采用基因芯片技术，对类风湿关节炎（RA）和系统性红斑狼疮（SLE）等自身免疫性疾病患者的基因表达谱及其与抗IL-6治疗疗效的相关性进行了全面分析。S100家族不仅参与RA的炎症反应，而且参与RA的骨代谢。在SLE患者中，ATP合成和DNA修复异常可能参与了SLE的发病机制。

We analyzed comprehensively gene expression profiles in patients with autoimmune diseases including rheumatoid arthritis(RA) and systemic lupus erythematosus(SLE) by DNA microarray and their correlation with the efficacy of anti-IL-6 therapy. S100 family was identified to be involved not only in inflammatory response but in bone metabolism in RA. In SLE patients, abnormal ATP synthesis and DNA repair were identified which may be involved in the pathogenesis of SLE.