Molecular basis of neuron-specific, activity-dependent regulation of the plasticity-related gene Arc

神经元即早基因Arc在长时程突触可塑性和长时程记忆形成中起关键作用，受脑内神经元活动的动态调节。通过这项研究，我们已经确定了Arc启动子中的几个基因组调控元件，并确定了有助于活性依赖性表达的转录因子。我们进一步揭示了一种新的机制，通过这种机制，Arc蛋白被定位，从而调节突触处的谷氨酸受体运输。

The neuronal immediate-early gene Arc, which plays critical roles in long-term synaptic plasticity and long-term memory formation, is dynamically regulated by neuronal activities in the brain. Through this study, we have determined several genomic regulatory elements in the Arc promoter, and have identified transcription factors that contribute to activity-dependent expression. We further uncovered a novel mechanism by which Arc protein is localized and thus regulates glutamate receptor trafficking at synapses.