Study of the switching mechanism by which microglia change their function

小胶质细胞增殖、产生有害因子、表达吞噬特性和呈递抗原的能力被认为是通过细胞内信号转导机制开启/关闭的。然而，大鼠面神经横断模型和体外模型的实验表明，小胶质细胞的功能可能是由细胞外空间的特定因素开启/关闭的，而不是由细胞内信号转导机制开启/关闭的。

The ability of microglia to proliferate, produce harmful factors, express phagocytic properties and present antigens has been considered to be switched on/off by intracellular signal transduction mechanism. However, the experiments using rat facial nerve transection model and in vitro model revealed that the abilities of microglia were suggested to be switched on/off by specific factors present in extracellular space, but not by intracellular signal transduction mechanism.