Development of novel methods for diagnosis of skin disorders using multiple acoustic parameters.

为了阐明使用声阻抗差异成像（AIDI）方法诊断皮肤疾病的新系统的潜力，我们将其用于硬币和猪皮。从直径为1.25 mm的熔融石英棒发射的中心频率为20 MHz的超声波聚焦在硬币和皮肤样品的表面上。通过基于反射型干涉的声阻抗测量方法确定声阻抗的差异。处理后的数据被生成为灰度图像，在其上映射最大测量振幅。我们把这个方法应用到一枚硬币上。猪皮，烧伤，并覆盖有厚度为0.2毫米的丙烯酸板。所有获得的处理后的图像几乎完全对应于放大的光学图像。在处理后的猪皮图像中，发现燃烧过程后有明显的差异。利用AIDI方法得到的处理图像不仅反映了起伏，而且还反映了其他信息，如弹性。总之，我们的系统使用AIDI有可能成为一个有用的方式诊断皮肤疾病。

To clarify the potential of a novel system using the acoustic impedance difference imaging(AIDI) method for diagnosis of skin disorders, we used it on a coin, and swine skin. An ultrasound wave with a central frequency of 20 MHz, emitted from a fused quartz rod with a diameter of 1.25 mm, was focused on the surface of the coin and skin samples. The difference in acoustic impedance was determined by the reflection-type interference-based acoustic impedance measurement method. The processed data were produced as grey-scale images on which the maximum measured amplitudes were mapped. We applied the method to a coin. Swine skin, burned and covered with an acrylic board with a thickness of 0.2 mm. All the processed images obtained corresponded almost exactly with the magnified optical ones. In the processed images of swine skin, a marked difference was found after the burning procedure. The processed images obtained using the AIDI method reflected not only the undulations but also other information such as elasticity. In conclusion, our system using AIDI has the potential to become a useful modality for the diagnosis of skin disorders.