Pharmacological studies on responsiveness of 5-hydroxytryptamine to overcome perioperative spasm of coronary artery bypass graft in diabetes mellitus

糖尿病(DM)可通过激活人胸内动脉(ITA)和隐静脉(SV)上的5-HT2A和5-HT1B受体来增强5-羟色胺(5-HT)引起的血管收缩。糖尿病大鼠血管对5-羟色胺的收缩增强是通过激活Rho/Rho激酶途径实现的。胰岛素抑制5-羟色胺引起的SV血管收缩。这些结果为预防5-羟色胺引起的血管痉挛提供了有用的药理学发现，当人ITA和DM患者的SV作为动脉移植物时。

Diabetes mellitus (DM) could enhance 5-HT-induced vasocontraction via the activation of 5-HT2A and 5-HT1B receptors of the human internal thoracic artery (ITA) and saphenous vein (SV). The enhanced vasocontractions to 5-HT in DM were mediated by the activation of Rho/Rho kinase pathways. Insulin inhibited 5-HT-induced vasocontraction in SV. These results inducate the useful pharmacological findings to prevent 5-HT-induced vasospasm when the human ITA and SV from patients with DM were used as an arterial graft.