Rhomboid regulates innate immunity via TNFα signaling

先天性免疫应答对于病原体防御是至关重要的，但当过度时可导致败血性休克。感染性休克的一种关键介质是TNFα，其在被蛋白酶TACE从质膜裂解后脱落到细胞间隙中。在此，我们报告了菱形家族成员RHBDF2与TACE相互作用并在体外和体内调节TNFα的脱落。我们的研究已经确定RHBDF2作为一种新的先天免疫调节因子，可能是调节脓毒症和病原体防御的重要靶点。

Innate immune responses are vital for pathogen defense but can result in septic shock when excessive. A key mediator of septic shock is TNFα, which is shed into intercellular spaces after cleavage from the plasma membrane by the protease TACE. Here we report that the rhomboid family member RHBDF2 interacts with TACE and regulates TNFαshedding in vitro and in vivo. Our study has identified RHBDF2 as a novel regulator of innate immunity that may be an important target for modulating sepsis and pathogen defense.