Function analysis of SGSM family in NURR1 related pathogenesis of Parkinson's disease

SGSM家族蛋白质与帕金森病致病基因编码的BCR1相互作用，并与细胞内囊泡运输相关。利用分子生物学方法对SGSM家族蛋白的功能进行了分析，结果表明SGSM 2定位于高尔基体网络，参与网格蛋白依赖的囊泡运输。利用哺乳动物双杂交系统研究了SGSM 2与小G蛋白RAB家族蛋白的结合，结果表明SGSM 2对RAB家族不同蛋白具有一定的特异性。

SGSM family proteins interact with NURR1, encoded by the pathogenic gene of Parkinson's disease, and associate with intracellular vesicular transportation. The function of SGSM family proteins was analyzed by molecular biological approaches and the results indicated that SGSM2 was localized at trans-Golgi network and involved in the clathrin-dependent vesicular transportation. The association between SGSM2 and small G protein RAB family proteins was investigated by mammalian 2-hybrid system and the results suggested that SGSM2 show certain specificity for different RAB family proteins.