Analysis on the roles of DOT1L histone methyltransferase in spermatogenesis

DOT1L H3K79甲基转移酶与哺乳动物生理现象之间的相互作用尚不清楚，尽管DOT1L在生物化学和分子生物学方面的功能已经得到了很好的研究。在这项研究中，我们通过分析雄性种系特异性mDot1l敲除小鼠和其他方法证明了mDot1l对精子发生至关重要。本研究为揭示DOT1L的新功能以及阐明组蛋白甲基转移酶在精子发生中的作用提供了基础证据。

The interaction between DOT1L H3K79 methyltransferase and physiological phenomenon in mammals remains to be clarified, though the functions of DOT1L in biochemistry and molecular biology have been well investigated. In this study we demonstrated mDot1l is essential for spermatogenesis by analysis of male germline specific mDot1l knockout mice and other methods. From this study we obtained a basic evidence to lead us to reveal a new function of DOT1L as well as clarified a role of a histone methyltransferase in spermatogenesis.