Investigation into differentiation effect of TGF beta for cancer stem cells in bone-metastatic prostate cancer cells
Investigation into differentiation effect of TGF beta for cancer stem cells in bone-metastatic prostate cancer cells
批准号:
21790390
负责人:
SATO Shinya
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
我们提出了骨转移性前列腺癌细胞中存在癌干细胞的可能性。我们还发现TGF β受体抑制剂在体内和体外均可降低前列腺癌细胞的增殖,明确TGF β信号调节作为前列腺癌新疗法的意义。
英文摘要
We raised the possibility of the existence of cancer stem cells in bone-metastatic prostate cancer cells. We also showed that prostate cancer cell proliferation was decreased by TGF beta1 receptor inhibitors in vivo and in vitro, and clarified the significance of TGF beta signaling regulation as a new prostate cancer therapy.
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原発巣・骨転移巣における前立腺癌幹細胞同定の試み
尝试鉴定原发肿瘤和骨转移中的前列腺癌干细胞
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[菰原義弘, Horlad Hasita, 大西紘二, 藤原章雄, 佐藤慎哉]
通讯作者:
佐藤慎哉
Tranilast suppresses prostate cancer growth and osteoclast differentiation in vivo and in vitro
曲尼司特在体内和体外抑制前列腺癌生长和破骨细胞分化
DOI:
--
发表时间:
2010
期刊:
The Prostate vol 70
影响因子:
--
作者:
[Sato S, Takahashi S, Asamoto M, Naiki T, Naiki-Ito A, Asai K, Shirai T]
通讯作者:
Shirai T
Trial to identify cancer stem cells in primary and bone metastatic prostate cancers
鉴定原发性和骨转移性前列腺癌中的癌症干细胞的试验
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[佐藤慎哉、白井智之, ら]
通讯作者:
ら
Traniast Suppresses Prostate Cancer Growth and Osteoclast Differentiation In Vivo and In Vitro
Traniast 在体内和体外抑制前列腺癌生长和破骨细胞分化
DOI:
--
发表时间:
2010
期刊:
The Prostate
影响因子:
--
作者:
[佐藤慎哉、白井智之, ら]
通讯作者:
ら
骨微小環境における前立腺癌幹細胞同定の試み
尝试鉴定骨微环境中的前列腺癌干细胞
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[佐藤慎哉、白井智之, ら]
通讯作者:
ら
共 11 条
Physiological role(s) of light-dependent, rhodopsin-independent PKA activity change in retinal rod photoreceptor cells.
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批准号:19K16087
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项目类别:Grant-in-Aid for Early-Career Scientists
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资助金额:$2.66万
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财政年份:2019
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负责人:SATO Shinya
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Elucidation of epigenome-mediated mechanism for growth supression in castration-resistant prostate cancer
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In search for genetic factors controlling the sexualization in diatoms
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批准号:15K18742
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资助金额:$2.66万
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财政年份:2015
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Research of new optical fiber measurement system in slope
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批准号:26350448
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
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财政年份:2014
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负责人:SATO Shinya
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A study on the network of children's environment in the adventure playground
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批准号:23601001
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2011
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负责人:SATO Shinya
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Study of an effective optical fiber sensor system for a slope and structure
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批准号:22510171
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2010
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负责人:SATO Shinya
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依托单位:
Basic Research for elucidation of chemo-resistance in mucinous adenocarcinoma cell.
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批准号:22791532
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.83万
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财政年份:2010
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负责人:SATO Shinya
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依托单位:
Elucidation and conquest of the taxane resistance based on cell cycle.
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批准号:19791151
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.58万
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财政年份:2007
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负责人:SATO Shinya
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依托单位:
海外基金