Control of tumor formation after transplantation in regenerative therapy with genetic engineering methods
Control of tumor formation after transplantation in regenerative therapy with genetic engineering methods
基因工程方法再生治疗中移植后肿瘤形成的控制
批准号：
21790528
负责人：
TAHARA Tsuyoshi
金额：
$2.75万
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2009
资助国家：
日本
项目状态：
已结题
起止时间：
2009 至 2010
中文摘要
翻译
基因疗法和细胞移植疗法有望成为治疗神经退行性疾病（如帕金森病和阿尔茨海默病）的突破。本研究从Oct 3/4基因启动子中分离出肿瘤或未分化细胞特异性启动子区，构建了GFP表达载体，该载体仅在未分化细胞中表达，如小鼠胚胎EB 5细胞，而在小鼠成纤维细胞Balb/3 T3 b细胞中不表达。
英文摘要
Gene therapy and cell transplantation therapy is expected to be a breakthrough for treating neurodegenerative disorders, such as Parkinson's and Alzheimer's disease. In this study, I could isolate the tumor- or non-differentiated cell-specific promoter region from Oct3/4 gene promoter and make the GFP expression vector, which works only in non-differentiated cell, such as mouse embryonic EB5 cell but not mouse fibroblast Balb/3T3b cells.
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会议论文
Transcriptional regulation of the neuroglobin gene expression in neural cells
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批准号：19700307
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项目类别：Grant-in-Aid for Young Scientists (B)
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资助金额：$2.38万
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财政年份：2007
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负责人：TAHARA Tsuyoshi
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依托单位：
海外基金
