Pathological mechanism for interferon-induced depression

为了评价干扰素诱导的自发活动和多巴胺能神经系统的变化，我们建立了包括视频活动监测系统和与多巴胺能神经传递相关的两种蛋白的正电子发射断层扫描（PET）成像的评价系统。我们阐明了正常活动的总持续时间的时间变化以及两种PET示踪剂在猴脑中的累积分布。此外，研究了麻醉状态对PET成像的影响。

In order to evaluate interferon-induced changes in locomotor activity and serotonergic nervous system, we established evaluating system containing both activity monitoring system using video and positron emission tomography(PET) imaging of two proteins related to serotonergic neurotransimission. We clarified temporal changes in total duration of normal activity as well as distributions of two PET tracer accumulations in monkey brain. In addition, effect of anesthetized state on the PET imaging was investigated.