Toxicogenomic analysis of pyrroloquinoline quinone of vitamin-like compound

在这项研究中，我们分析了细胞毒性和基因表达在成骨过程中加入吡咯喹啉醌（PQQ）显示维生素样生物活性的小鼠成骨细胞。PQQ浓度为0。在分化后的成骨过程中，PQQ的存在增加了已知为成骨标志酶的碱性磷酸酶的酶活性，尽管成骨细胞表现出矿化沿着PQQ浓度依赖性的降低。

In this study, we analyzed cytotoxicity and gene expression during osteogenesis by addition of pyrroloquinoline quinone(PQQ) showing vitamin-like bioactivity on murine osteoblast. The osteoblast treated with PQQ showed cytotoxicity and growth inhibition at the concentration of 0. 1 mM. During osteogenesis after differentiation, the presence of PQQ increases the enzyme activity of alkaline phosphatase known as the marker enzyme of the osteogenesis, although the osteoblast exhibited the decreasing of mineralization along with the concentration-dependent of PQQ.