In silico study of mechanism and therapy of chronic atrial fibrillation based on the human atrial numerical model

我们构建了人类心房的计算机模型，并进行了模拟（在silico）的慢性心房颤动（AF）。然后我们发现成纤维细胞增殖促进AF慢性化并形成复杂碎裂心房电图（CFAE），被称为慢性AF的有效消融靶点（成纤维细胞CFAE假说）。我们的研究结果有助于更好地理解CFAE靶向房颤消融的机制，并将改善难治性慢性房颤消融的结果。

We constructed the computer model of human atria, and conducted simulations (in silico) of chronic atrial fibrillation (AF). Then we found that fibroblast proliferation promotes AF chronicity and forms complex fractionated atrial electrogram (CFAE), known as the effective ablation target for chronic AF (Fibroblast-CFAE hypothesis). Our findings could contribute to better understanding of the mechanisms underlying CFAE-targeted AF ablation, and will improve the outcome of refractory chronic AF ablation.