Identification of MURC, muscle-restricted coiled-coil protein, and molecular characterization of MURC-induced cardiac dysfunction and arrhythmia

我们鉴定了一种肌肉限制性卷曲蛋白MURC，发现MURC定位于心肌细胞质膜上的小窝，并与小窝蛋白-3、PTRF/Cavin-1、SDPR/Cavin-2和SRBC/Cavin-3相关。我们还发现，在心肌细胞中过表达MURC会导致小窝扩张，而在心脏中表达MURC的转基因小鼠则表现出心肌细胞中小窝的变形。由于在心脏中表达MURC的转基因小鼠表现出心脏功能障碍和心律失常，我们正在研究MURC诱导的心脏功能障碍和心律失常的分子机制。

We identified a muscle-restricted coiled-coil protein, MURC, and found that MURC was localized to caveolae at the plasma membrane of cardiomyocytes and was associated with caveolin-3, PTRF/cavin-1, SDPR/cavin-2, and SRBC/cavin-3. We also found that overexpression of MURC in cardiomyocytes induced distension of caveolae and transgenic mice expressing MURC in the heart exhibited deformation of caveolae in cardiomyocytes. Since transgenic mice expressing MURC in the heart shows cardiac dysfunction and arrhythmia, we are investigating the molecular mechanisms responsible for MURC-induced cardiac dysfunction and arrhythmia.