The significance of cardio-renal interaction via the rapid signal transduction system of peroxisome proliferator-activated receptorγ

噻唑啉二酮类药物（TZDs）是一种治疗糖尿病的药物，具有水肿和充血性心力衰竭的副作用。我们已经通过生理学研究和用培养细胞和大鼠和小鼠的肾脏进行蛋白质测定来研究这种副作用的机制。我们发现TZDs通过快速信号转导系统增强钠从肾近端小管的重吸收，而不依赖于转录系统。这可能会导致开发新的糖尿病药物，没有这样的副作用。(Cell代谢13（5），第550 -561页，2011年）

Thiazolinediones (TZDs), the medical drug used for the treatment of diabetes, have the side-effects of edema and congestive heart failure. We have investigated the mechanism of this side-effect by physiological studies and assays of proteins with culture cells and the kidneys of rats and mice. We found that TZDs enhance sodium reabsorption from renal proximal tubules via rapid signal transduction system, independently of transcription system. This may lead to develop new drugs for diabetes that do not have such side effects. (Cell Metabolism 13(5), pp.550-561, 2011)