Contribution of (pro)renin receptor to the development of insulin resistance in obese hypertension

我们研究了肥胖和瘦高血压大鼠（前）肾素受体阻滞剂、诱捕剂和争夺剂对胰岛素抵抗的影响。腹膜糖耐量试验结果肥胖组血糖水平高于未治疗组。scramble治疗组血糖无明显变化，而诱饵治疗组血糖有明显改善。腹腔胰岛素耐量试验比较胰岛素给药前和给药后90分钟和120分钟的血糖水平。匆忙治疗没有改善降低血糖水平，但诱饵治疗有所改善。肥胖诱饵治疗组骨骼肌Ark磷酸化水平高于肥胖未治疗组。

We studied the influence of insulin resistance when we administered obese and lean hypertensive rats (pro) renin receptor blocker, the decoy and its scramble for 12 weeks. Intraperitoneal glucose tolerance test results in obese was higher than lean in the glucose level in the untreated group. The scramble treatment group had no change in blood glucose, but the decoy treatment group was improved. The intraperitoneal insulin tolerance test compared before and after administration of insulin to glucose levels after administration of insulin in 90 minutes and in 120 minutes. The scramble treatment did not improve lowering blood glucose levels, but the decoy treatment improved. The obese decoy treatment group had increased the skeletal muscle Ark phosphorylation more than the obese untreated group.