Elucidation of molecular mechanisms of the leptin resistance

瘦素(L)/胰淀素(A)联合给药显著减少瘦素抵抗饮食诱导的肥胖小鼠的摄食量和体重，而L或A单独给药没有影响。L/A合用可增强胰岛素敏感性，降低组织甘油三酯含量，增加骨骼肌中α-2AMP激活的蛋白激酶活性。本研究证实了L/A合用对糖尿病小鼠糖脂代谢的有利作用，提示L/A合用作为肥胖相关糖尿病的一种新的降糖治疗方法具有潜在的临床应用价值。

Leptin (L)/amylin (A) co-administration significantly reduced food intake and body weight in leptin-resistant diet-induced obesity mice, while administration of L or A alone had no effects. L/A co-administration enhanced insulin sensitivity associated with decreased tissue triglyceride content and increased α2 AMP-activated protein kinase (AMPK) activity in skeletal muscle. This study demonstrates the beneficial effect of L/A co-administration on glucose and lipid metabolism in DIO mice, indicating the possible clinical usefulness of L/A co-administration as a new anti-diabetic treatment in obesity-associated diabetes.