Development of an artificial placenta using a premature lamb model

本研究的目的是研制一种能够维持胎儿血液循环的无泵动静脉体外生命支持回路的人工胎盘，使绵羊胚胎在维持胎儿循环的同时存活15小时以上。多巴胺可使平均动脉压一过性升高。然而，即使人工胎盘的气体交换保持不变，血乳酸也会随着时间的推移而增加，心功能逐渐恶化。在我们的实验中，平均动脉压的升高可能是通过全身血管收缩实现的，这可能是由于人工胎盘血流增加而导致全身器官血流量减少，从而导致全身循环衰竭。通过控制每个阻力来保持体循环和循环循环可能很重要。

The purpose of this study was to develop an artificial placenta in the form of a pumplessarteriovenous extracorporeal life support circuit that could maintain fetal circulation.Sheep fetuses survived for more than 15 hours with the artificial placenta while maintaining fetal circulation. Dopamine could increase the mean arterial pressure transiently. However, blood lactatewas increased and the cardiac performance was gradually deteriorated over time even while the gas exchange ofthe artificial placenta was maintained. Elevated mean arterial pressurein our experiment might be achieved by systemic vasoconstriction, which led to decreased systemic organ flowdue to increased artificial placental flow, resulted in systemic circulatory failure. It may be important to retain both systemic and circuit circulation by controlling each resistance.