Molecular oncological study on lung cancer among atomic-bomb survivors

即使在原子弹爆炸60多年后的今天，原子弹幸存者患肺癌的风险仍然很高。然而，辐射暴露如何影响肺癌发展的分子机制长期以来仍不清楚。因此，本研究旨在通过分析与肺癌发生相关的分子改变，探讨原子弹爆炸幸存者肺癌的分子肿瘤学特征。结合我们的初步研究，本研究获得的结果表明，某些基因突变的频率、类型和DNA甲基化等分子改变可能与辐射暴露有关。

Risk of lung cancer among atomic-bomb(A-bomb) survivors remains high even now, more than 60 years after the bombings. However, the molecular mechanisms behind how radiation exposure influences the development of lung cancer have long remained unclear. Therefore, this study aimed to investigate the molecular oncological characteristics of lung cancer among A-bomb survivors by analyzing molecular alterations associated with lung carcinogenesis. In combination with our preliminary study, results obtained from this study suggest the possibility that molecular alterations such as frequencies of certain gene mutations and the types and DNA methylation may be associated with radiation exposure.