Effect of prostaglandin analogues on contraction and degradation of collagen gel mediated by human scleral fibroblasts

前列腺素类似物可改善葡萄膜巩膜外流，但其机制和生理学尚不清楚。在这项研究中，前列腺素类似物诱导胶原凝胶收缩介导的人巩膜成纤维细胞。前列腺素类似物的这种作用似乎依赖于应力纤维的形成以及人巩膜成纤维细胞中丝裂原活化蛋白激酶、粘着斑激酶、Rho相关激酶的激活。因此，前列腺素类似物可能通过影响巩膜成纤维细胞的收缩性来影响巩膜结构，从而改善葡萄膜巩膜流出。

Prostaglandin analogues improve uveoscleral outflow, but its mechanism and physiology of uveoscleral outflow are still unknown. In this study, prostaglandin analogues induced collagen gel contraction mediated by human scleral fibroblasts. This action of prostaglandin analogues appeared to depend on the formation of stress fibers as well as the activation of mitogen-activated protein kinase, focal adhesion kinase, Rho-associated kinase in human scleral fibroblasts. Prostaglandin analogues might therefore influence scleral structure by affecting the contractility of scleral fibroblasts, resulting in improvement of uveoscleral outflow.