The study of regulation of bone metabolism and hematopoietic stem cell niche by steroid hormone and these target factors

为了阐明雌激素对骨代谢和造血干细胞生态位的调节机制，我们采用了雌激素处理的日本雄性鹌鹑的髓质骨形成模型。髓质骨改建受控于OPG/RANKL/RANK系统。在髓内骨形成过程中，骨髓细胞群由未分化的细胞向破骨细胞前体细胞转化，髓内的成骨细胞起着生态位细胞的作用。这些结果提示雌激素可能与造血干细胞生态位的调节有关。

To clarify the regulation of mechanism of bone metabolism and hematopoietic stem cell niche by estrogen, we used the medullary bone formation model of estrogen-treated male Japanese quails. Medullary bone remodeling was under the control of OPG/RANKL/RANK system. During medullary bone formation period, the population of bone marrow cells shifts from undifferentiated cells to osteoclast precursor cells and osteoblasts on the medullary bone act as a niche cells. These results suggest that estrogen may be related to regulate of hematopoietic stem cell niche.