Clarification of Novel Metastatic mechanism in Oral Squamous Cell Carcinoma

本研究的目的是利用携带人类全部基因的DNA微阵列技术，寻找口腔鳞状细胞癌转移相关新基因，为口腔鳞癌转移的诊断和肿瘤分级的评估奠定基础。基于对口腔组织、口腔鳞癌组织和淋巴结转移组织的整体基因表达分析，已列出了75个候选基因，包括锌指DHHC14(ZDHHC14)和脾酪氨酸激酶(SYK)。它表明，可能存在超过50个表达受损的基因，这些基因在每个病例中都被普遍识别，如果不是在所有病例中，至少在口腔鳞状细胞癌中是这样。

The aim of this study was to identify novel metastasis-associated gene of oral squamous cell carcinoma by using DNA microarray on which all human genes are carried in order to make it possible to diagnose metastasis as well as to evaluate grade of tumor. Based on a global gene expression analysis on oral tissue, oral squamous cell carcinoma tissue and lymph node metastasis tissue, 75 of candidate genes including zinc finger DHHC-type containing 14(ZDHHC14) and Spleen tyrosine kinase(SYK) have been listed up. It has suggested a possible existence of more than 50 of genes with impaired expression, which are commonly recognized in each case, at least in oral squamous cell carcinoma, if not in all cases.