Development of micelle and vesicle based on amphiphilic compound bearing various sugar moieties and estimation of their cell recognition abilities.

本研究的目的是开发基于两亲性化合物的稳定胶束和/或囊泡，以便将其应用于药物输送系统(DDS)的胶囊。众所周知，半乳糖选择性地与肝脏表面的细胞相互作用。因此，我们合成了以半乳糖为亲水基团与各种亲油基团组成的两亲性化合物，并对其聚集体的性质进行了研究。用2，2-二(十八烷氧甲基)-1-丙醇和2-苄氧甲基-2，2-二(十八烷基氧甲基)-1-乙醇在半乳糖上形成糖苷键，分别得到化合物1和2。通过分光光度和透射电子显微镜观察发现，化合物1的聚集体具有囊泡结构，其中包含一个水相。

The purpose of this study is the development of stable micelle and/or vesicle based on amphiphilic compounds in order to apply them to the capsule for the drug delivery system(DDS). It is well-known that galactose selectively interacts with the cell on the surface of a liver. Thus, the amphiphilic compounds composed of galactose group as a hydrophilic moietry and various lipophilic moietyies were synthesized and the property of their aggregates were investigated. The glycoside bonds were formed on galactose using 2, 2-bis(octadecyloxymethyl)-1-propanol and 2-benzyloxymethyl-2, 2-bis(octadecyl-oxymethyl)-1-ethanol to give compounds 1 and 2, respectively. It was found by using the spectrophotometry and transmission electron microscope(TEM) that the aggregate of compound 1 has the vesicle structure, which includes an aqueous phase inside.