Functional significance of integrin-αvβ3 in the regulation of metastatic potential of malignant melanoma and its therapeutic implication

我们评价了整合素-αvβ3在恶性黑色素瘤预后和治疗反应中的作用。获得抗癌药物抗性的黑素瘤细胞显示整合素-αvβ3显著上调。化疗耐药黑色素瘤上的整合素-αvβ3操纵树突状细胞诱导耐受原活性，从而损害抗肿瘤免疫应答。这些发现证实了新的分子机制，即肿瘤对抗癌治疗的耐药性与宿主抗肿瘤免疫力的损害有关。

We evaluated the role of integrin-αvβ3 on the regulation of prognosis and therapeutic response of malignant melanoma. The melanoma cells that acquire the resistance to anticancer drugs displayed a significant upregulation of integrin-αvβ3. The integrin-αvβ3 on the chemoresistant melanoma manipulates dendritic cells to induce tolerogenic activities, thereby impairing antitumor immune responses. These findings verified novel molecular machineries whereby tumor resistance to anticancer therapeutics is associated with impairment of host antitumor immunity.