Development of Clathrate-type single-cell array chip using thermoresponsive polymer

我们通过提供具有光交联和热交联能力的热敏性聚合物来开发生物抗蚀剂。该生物抗蚀剂可用于光刻和热纳米压印的微细加工。而微小的生物抗蚀剂图案可以通过改变温度进行可逆改变。此外，我们开发了一种笼型单细胞阵列芯片，该芯片由多个生物抗蚀剂孔图案阵列组成，可以捕获和释放单细胞等小物体。

We developed Bio-resist by providing thermoresponsive polymer with photocrosslinking and thermal cross-linking capabilities. The Bio-resist can be used for micro fabrication by photolithography and thermal-nanoimprint. And small Bio-resist patterns could be changed reversibly by changing temperature. Moreover, we developed a clathrate-type single-cell array chip which consists of many arrays of Bio-resist hole patterns where small objects such as single-cells can be captured and released.