Studies on search and action mechanism of new functional substances of a constituent of Porphyra yezoensis

为了阐明紫菜对脂质吸收的影响，我们将紫菜样品给予大鼠。通过加热菜籽油和紫菜细粉（RNAO）获得样品。血液中脂质浓度与对照组相比，RNAO均偏高。因此，为了揭示该物质，我们使用从紫菜中提取的水溶性膳食纤维（卟啉）进行了脂质负荷试验，出乎意料地抑制了脂质吸收。此外，还研究了这种效应是否与紫菜溶液的粘度有关。结果表明，它并不打算通过粘度促进脂质吸收。这些结果是测量血脂水平。为了更准确地评价，接下来的实验是检查吸收进入淋巴。结果，淋巴流量和磷脂浓度没有受到影响，但脂质浓度变高。这些结果表明，RNA O可能促进脂质吸收。此外，我们推进了从紫菜中分离和纯化胰岛素样作用物质，但没有鉴定活性物质

In order to clarify the effect on the lipid absorption of Nori, we administered Nori sample to rats. The sample was obtained by heating rapeseed oil and Nori fine powder (RNAO). The lipid concentration in the blood compared to the control group, RNAO were high. Therefore, in order to reveal the agent, we subjected to a lipid load test using water-soluble dietary fiber (porphyran) extracted from Nori, unexpectedly lipid absorption was inhibited. Moreover, this effect was investigated whether it was depended on the viscosity of Nori solution. It was shown that it is not intended to promote lipid absorption by the viscosity. These results were measured lipid level in blood. In order to evaluate more accurately, the next experiment was examined absorption into the lymph. As a result, lymph flow and the phospholipid concentration were not influenced, but lipid concentration became higher. These observations suggest that RNAO may promote the lipid absorption. Further, we advanced the separation and purification of the insulin-like action substance from Nori, but did not lead to identification of the active substance