Construction of Separation Systems for Biomacromolecules by Using Self-Organized Nanotube Hydrogels

新型楔形两亲分子在水中自组织，形成响应pH刺激的纳米管水凝胶。纳米管水凝胶具有两个独立的空间，由纳米管之间形成的三维网络和纳米管本身的一维中空圆柱体组成。将纳米管水凝胶作为筛子引入毛细管电泳法，可以构建生物大分子的分离体系。成像技术表明，内径为8 nm的一维纳米管中空圆柱体作为DNA分离的功能空间。

Novel wedge-shaped amphiphiles self-organized in water to from nanotube hydrogels responding on pH stimulus. The nanotube hydrogel possessed two independent spaces consisting of three-dimensional meshworks formed between nanotubes and one-dimensional hollow cylinder of the nanotube itself. Introduction of the nanotube hydrogel as sieves into the capillary electrophoresis allowed to construct a separation system for biomacromolecules. Imaging technique showed that the one-dimensional hollow cylinder of the nanotube with 8 nm inner diameter acts as a functional space for the DNA separation.