Strategy for the early prevention of sarcopenia and its effects on community-dwelling elderly people

社区老年妇女肌肉减少症患病率为22.1%。肌肉减少组和正常组之间的几个变量的比较表明，肌肉减少妇女有显着较低的小腿围，骨密度，体重指数，肌肉质量，和老年人。此外，与正常受试者相比，肌肉减少症女性有更高的骨质疏松症、福尔斯和骨折发生率。评估运动和氨基酸补充剂在增强社区老年肌肉减少症妇女肌肉质量和力量方面的有效性。155名75岁及以上的女性被定义为肌肉减少症，并随机分配到四组之一：运动和氨基酸补充剂（运动+ AAS; n = 38），运动（n = 39），氨基酸补充剂（AAS; n = 39），或健康教育（HE; n = 39）。运动组每周参加两次60分钟的综合训练，AAS组服用富含亮氨酸的必需氨基酸米3g。 ...更多信息 一天两次，持续三个月。使用生物电阻抗分析确定身体组成。在基线和3个月干预后收集访谈数据和功能性健身参数，如肌肉力量和步行能力。在腿部肌肉质量（P = 0.007）、通常步行速度（P = 0.007）和膝关节伸展强度（P = 0.017）方面观察到显著的组×时间相互作用。组内分析显示，所有三个干预组的步行速度显著增加，运动+ AAS组和运动组的腿部肌肉质量显著增加，运动+ AAS组的膝关节伸展强度显著增加（增加9.3%，P = 0.010）。运动+ AAS组腿部肌肉质量和膝关节伸展强度改善的比值比是HE组的4倍多（比值比= 4.89，95%置信区间= 1.89-11.27）。这些数据表明，运动和AAS一起可能是有效的，不仅提高肌肉力量，但也结合变量的肌肉质量和步行速度和肌肉质量和力量的肌肉减少症的妇女。少

The prevalence of sarcopenia was 22.1% in community-dwelling elderly women. The comparison of several variables between the sarcopenic and normal group shows that sarcopenic women had significantly lower calf girth, bone mineral density, BMI, and muscle mass, and were older. Additionally, sarcopenic women had a higher history of osteoporosis, falls, and fractures rates compared with normal subjects. To evaluate the effectiveness of exercise and amino acid supplementation in enhancing muscle mass and strength in community-dwelling elderly sarcopenic women. One hundred fifty-five women aged 75 and older were defined as sarcopenic and randomly assigned to one of four groups : exercise and amino acid supplementation (exercise + AAS; n = 38), exercise (n = 39), amino acid supplementation (AAS; n = 39), or health education (HE; n = 39). The exercise group attended a 60-minute comprehensive training program twice a week, and the AAS group ingested 3 g of a leucine-rich essential amino acid mi … More xture twice a day for 3 months. Body composition was determined using bioelectrical impedance analysis. Data from interviews and functional fitness parameters such as muscle strength and walking ability were collected at baseline and after the 3-month intervention. A significant group × time interaction was seen in leg muscle mass (P = .007), usual walking speed (P = .007), and knee extension strength (P = .017). The within-group analysis showed that walking speed significantly increased in all three intervention groups, leg muscle mass in the exercise + AAS and exercise groups, and knee extension strength only in the exercise + AAS group (9.3% increase, P = .010). The odds ratio for leg muscle mass and knee extension strength improvement was more than four times as great in the exercise + AAS group (odds ratio = 4.89, 95% confidence interval = 1.89-11.27) as in the HE group. The data suggest that exercise and AAS together may be effective in enhancing not only muscle strength, but also combined variables of muscle mass and walking speed and of muscle mass and strength in sarcopenic women. Less