Effects of nuclear receptor-activating compounds produced By microalgae on aquatic animal

在水华蓝藻中发现了一种新的维甲酸类似物--7-羟基维甲酸。该类似物对核受体维甲酸受体(RAR)具有拮抗活性。新的类似物是从大规模培养的螺旋藻(TU-3)中分离出来的，在所有供试的蓝藻菌株中都发现了类似物。该类似物通过顺反异构化，包括酮-烯醇互变异构化，存在四种异构体的混合物。该类似物对RAR的激活活性是全反式维甲酸(ATRA)的一半。与全反式维甲酸相比，该类似物在UV-A下非常稳定。7-羟基维甲酸在UV-A下的稳定性表明，生活在水华发生水域的两栖动物和鱼类可能会受到暴露，并具有致畸作用。

A novel analogue of retinoic acid, 7-hydroxy retinoic acid, was found in waterbloom-forming cyanobacteria. The analogue had an agonistic activity against retinoic acid receptor (RAR) as a kind of nuclear receptors. The novel analogue was isolated from mass-cultured Spirulina sp.(TU-3).The analogue was found in all-tested strains of cyanobacteria. The analogue exist a mixture of four isomers by cis-trans isomerization including keto-enol tautomerism. The agonistic activity of the analogue against RAR was a half of all-trans retinoic acid (ATRA). The analogue was far-stable under UV-A compared with ATRA. The stability of 7-hydroxy retinoic acid under UV-A suggest that amphibians and fishes living in waterblooms occurring waters may be exposure, and give teratogenic effects.