Structural protective effects of glycosaminoglycans on articular distraction in joint diseases in animals

关节内透明质酸（HA）和皮下戊聚糖聚硫酸钠（PPS）已被用于治疗人类和动物骨关节炎（OA）的疼痛和炎症。本研究结果表明，外源性HA可以刺激滑膜成纤维细胞和软骨细胞产生内源性长链HA，从而稳定关节软骨细胞的细胞环境。PPS还能抑制白细胞介素(IL)-1β-诱导的p38和细胞外信号调节激酶（ERK）的磷酸化，进而抑制NF-κB的核易位和基质金属蛋白酶-3的生成。白细胞介素(IL)-1β刺激的软骨细胞。这些数据将这些分子的临床疗效转化为HA和PPS对OA动物的临床软骨保护作用。

Intra-articular hyaluronic acid (HA) and subcutaneous pentosan polysulfate sodium (PPS) have been used for the management of pain and inflammation of osteoarthritis (OA) in humans and animals. As the results of this study, it was indicated that exogenous HA could stimulates both synovial fibroblasts and chondrocytes to produce endogenous long chain HA which contribute stabilization of cellular environment of articular chondrocytes. It was also suggested that PPS could inhibit interleukin (IL)-1β-induced phosphorylation of p38 and extracellular signal-regulated kinase (ERK), then suppress nuclear translocation of NF-κB and matrix metalloproteinase-3 production in cultured chondrocytes. on interleukin (IL)-1β stimulated chondrocytes. These data would translate the clinical efficacy of these molecules for clinical chondroprotective effects of HA and PPS in animals with OA.