Potential mechanisms and therapeutic strategies of sarcopenia

为了研究骨髓干细胞和运动对年龄相关性骨骼肌萎缩和无力（肌肉减少症）的影响，我们在衰老加速倾向小鼠（SAMP10） 8周龄时移植野生型（C57BL/6）骨髓。对照非移植和移植SMAP10随机分为2组（从25周龄开始），进行或不进行运动训练。在40周龄时进行肌肉质量、耐力和组织生化分析。这些研究为骨髓源性干细胞向骨骼肌细胞分化提供了证据。野生型小鼠骨髓移植可改善年龄相关性骨骼肌萎缩无力（骨骼肌减少症），提示骨髓细胞老化可能是SAMP10骨骼肌减少症的原因之一。此外，运动可以通过防止肌肉蛋白降解和线粒体活化SAMP10来预防肌肉减少症。

To examine the effect of bone marrow stem cells as well as exercise on the age-associated skeletal muscle atrophy and weakness (sarcopenia), senescence-accelerated-prone mouse (SAMP10) were transplanted with bone marrow of wild-type (C57BL/6) at 8 weeks of age. Control non-transplant and transplant SMAP10 were randomly assigned to 2 groups with or without exercise training (from 25 weeks of age). At 40 weeks of age, muscle weight, endurance capacity, and the tissue biochemical analysis were carried out.These studies provide the evidences that the bone marrow-derived stem cells differentiate into skeletal muscle cells. Bone marrow transplantation of wild type mice improves the age-associated skeletal muscle atrophy and weakness (sarcopenia), suggesting that aging of bone marrow cells may contribute to the cause of sarcopenia of SAMP10. In addition, exercise can prevent sarcopenia through the prevention of muscle protein degradation and mitochondrial activation in SAMP10.