Preparation of retina-targeted siRNA delivery system possessing stability in blood

转铁蛋白（Trf）修饰的脂质体包封核酸如siRNA并在血流中具有稳定性，其被开发用于有效地将基因递送到已知难以从血流递送物质的眼后段（特别是视网膜）。体内外研究结果表明，该系统可作为非侵入性应用，如滴眼液，并可通过改善脂质成分来增加光和热激活功能。

The transferrin(Trf)-modified liposomes which encapsulates nucleic acids such as siRNA and has stability in blood stream is developed for effective gene delivery to the posterior segment of eye (particularly retina) which has been known to be hard to deliver substances from blood stream. The results in vivo and in vitro study suggestthat the system is available as non-invasive application such as eye drop and could be added light- and thermo-activating function by improving components of lipids.